Diagnosing and Treating Rhinosinusitis: New Guidelines

The Infectious Diseases Society of America has published its first-ever recommendations for the diagnosis and management of acute bacterial rhinosinusitis (ABRS) infections.[1] The guidelines used the new GRADE system (Grading of Recommendations Assessment, Development and Evaluation), which is designed to more clearly assess the quality of evidence and report the strength of recommendations. The ABRS guidelines were posted online...

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Diabetes Prevention With Metformin Is Safe, Well-Tolerated

 Long-term treatment with metformin is safe for preventing or delaying the development of type 2 diabetes, according to an article published in the April issue of Diabetes Care.New data from the open-label Diabetes Prevention Program Outcomes Study (DPPOS) demonstrate that metformin is linked to "modest but durable weight loss" of 2% body weight over the course of 10 years, and appears to be safe and well tolerated.The findings support the conclusions of the original 3-year DPP double-blind study showing that use of metformin (850 mg...

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Diabetes Risk Increased by 3 Independent Factors

Insulin resistance (IR), overweight/obesity, and fatty liver commonly occur together but are independently associated with an increased risk of developing type 2 diabetes mellitus, according to results from a Korean study published onlineFebruary 14 and in the April print issue of Diabetes Care.Investigators led by Ki-Chul Sung, MD, PhD, from the Sungkyunkwan University School of Medicine in Seoul, Republic of Korea, found that IR was linked to an almost quadrupled risk for diabetes (odds ratio [OR], 3.92; 95% confidence interval [CI],...

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